Polynucleotides

DNA and RNA are two examples of polynucleotides. The Mastelli Aesthetics brand range of products contain polynucleotides (DNA fractions) obtained from salmon or trout sperm through a patented technology featuring a high degree of purity and safety (PN-HPTTM). Polynucleotides are used in regenerative medicine to promote tissue and wound healing. In aesthetic medicine they are used to improve the quality and appearance of skin and can also be used to restore hair.

The polynucleotides are distilled into a range of concentrations and suspended in water for injection. Plenhyage strong 50mg/2mls, Plinest^TM 40mg/2mls, Newest^TM 20mg/2mls

*Newest^TM also contains hyaluronic acid and mannitol to boost skin hydration and longevity.

The polynucleotides in the Mastelli Aesthetics range are highly purified and then sterilised using patented technology. The purification process removes all protein molecules so there is no risk of allergy.

The science is evidenced based and there are 90 published scientific papers demonstrating safety and efficacy, and 34 randomised comparative trials.

Polynucleotides have been used in regenerative medicine since 1986 to promote tissue and wound healing and more recently in aesthetic medicine to improve skin quality and support recovery and results following invasive procedures. There are no known risks associated with the injection of polynucleotides. Your clinician will explain the temporary side-effects you may experience.

• Dull skin
• Course skin
• Wrinkles
• Uneven Pigmentation
• Redness
• Dark circles
• Acne scarring
• Stretch marks
• Surgical scarring
• Hair loss
• Not just for the face; hands, neck, chest, arms, knees. Any skin, anywhere on the body.

Polynucleotides stimulate a receptor on cells which positively influences the following;

• Cell proliferation
• The repair and regenerative actions of fibroblast cells
• The production of collagen and elastin
• The production of hyaluronic acid
• The production of healthy new micro-blood vessels
• The function of melanocytes which produce pigment
• The reduction of inflammation
• The regulation of water balance

The formation of fat cells which support the skin

Treatment is administered by injection into the superficial layer of the skin.

The clinician uses either a fine needle or a cannula to administer multiple micro-doses into the target area.

A course of three or four treatments 3 weeks apart s recommended to achieve optimum results.

The results are not instant, but improvement can be noted from about three weeks and continues to improve over a twelve week period. Patients report a general improvement in the radiance of the skin, the skin should feel smoother and better hydrated. Pores, uneven colouration and texture can be improved. Fine lines and wrinkles are improved. The size, texture, depth and colouration of scarring can be improved.

Results will vary between individuals as the outcome is dependent upon the biological response of the individual and lifestyle factors.

Longevity does vary between individuals.  Polynucleotides do not arrest the ageing process; therefore a maintenance treatment is recommended every six months. Life-style factors can affect longevity.  If you choose not to maintain the results with further treatment, your skin will return to its pre-treatment state over time.

Because bruising and swelling can occur and may take time to settle, it is not advisable to have treatment just before an important event. Although the majority of patients suffer only minor side effects related to the injections, it is best to allow sufficient time for any possible side effects to resolve.

For 12-24 hours you may have visible bumps in the skin. Pin prick marks/scabs may take 5 days to resolve. Bruising can take up to 2 weeks to resolve. Though make-up can be worn the next day. Your clinician will advise. Do not schedule treatment when you have other procedures or medical treatments planned, without first discussing with your clinician. This includes, but is not limited to, vaccinations, massage, facials, dental appointments and surgery.

It is best not to schedule treatment just before a holiday in the sun. Discuss with your clinician.

The clinician will take a detailed medical history to ensure you have no conditions that might increase risk of unwanted side effects, consultation is also important to discuss your expectations and whether this treatment is able to meet them.

Treatment can be uncomfortable.

A topical anaesthetic cream will be applied before treatment to numb the skin.

Do read all the information provided to you and highlight anything you need to ask about. Check the clinic terms and conditions before attending.

Make-up

All make up will need to be removed prior to treatment, so please come ‘fresh faced’ if possible.

Check medicines and supplements

Aspirin, Ibuprofen and a range of dietary supplements including St. John’s Wort, fish oils, Gingko Biloba, Vitamins C and E- may all contribute to bruising and are best avoided 24 hours before treatment.

Alcohol

Don’t drink alcohol the night before, it will increase your risk of bruising.

Healthy skin and feeling well?

Check with the clinic before attending if any of the following apply;

• Cold sore, brewing, active or recent and not quite healed.
• Acne break-out
• Feeling unwell- including colds, coughs, sore throats etc.
• New diagnosis or medicines
• New injury for which you are taking pain medicines
• Appointments with the dentist; recent, or planned within 10 days of the treatment
• Travel plans within 10 days of the treatment.

Bring your reading glasses with you.

You will need to read and sign some forms

Patient tips and tricks

Sun glasses are useful to hide treatment around the eyes after treatment.

Silk scarves or polo necks for treatment on the neck.

Jewelry

Leave jewelry at home, especially large earrings, or facial piercings, bring a purse to keep them safely if you have to remove.

You may continue with normal activities, but it is likely there will be small bumps just under the skin that will be visible and may take from 3-12 hours to settle. It is possible you will have some redness, pin prick marks, possibly swelling.  Possibly bruising. Swelling is likely to settle within 48 hours.  Bruising may be more apparent the next day and can take up to 10-14 days to resolve.

For 6 hours

To avoid infection;
•    Do not reapply make-up
•    Do not wear tight head-gear such as bike or cycle helmets, or riding hats.  These will not be clean and may increase risk of infection.
•    Keep your hands clean and avoid touching your face
•    Avoid using your mobile phone against the treated area
•    Don’t let pets lick your face
•    Don’t pick or scratch the treated area.

For 12-24 hours
It is advisable to avoid aspirin and alcohol which can make any swelling or bruising worse

Until any redness, swelling or bruising has settled
To minimize discomfort and help it settle;
Avoid extremes of heat or cold or vigorous exercise, until any swelling, bruising or tenderness has settled.

Swelling may worsen in the first 24 hours, and then should settle within the first few days. Cold packs can be helpful in reducing swelling. Be sure not to apply ice directly to the skin or for too long. This can cause a ‘freeze burn’.

Bruising may take a few days to appear, arnica or bromelain can be helpful in clearing bruising.  Tenderness should settle as swelling goes down.

If you have any symptoms which concern you or get worse rather than better after 12 hours please don’t hesitate to contact the clinic for further advice.

Please make sure you have booked your follow-up treatment in 3 weeks’ time, or as advised by your clinician.